Interações medicamentosas
Imipramine + Isocarboxazid
Gravidade: Contraindicada
Imipramine and Isocarboxazid: contraindicated interaction.
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Resumo
Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and imipramine is a tricyclic antidepressant that blocks serotonin and noradrenaline reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
O que esta interação significa em palavras simples
Imipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imipramine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Por que acontece
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
O que fazer
Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting imipramine, and at least 14 days after stopping imipramine before starting isocarboxazid.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Imipramine
- Dronedarone + Imipramine Contraindicada
- Imipramine + Phenelzine Contraindicada
- Imipramine + Pimozide Contraindicada
- Imipramine + Rasagiline Contraindicada
- Imipramine + Safinamide Contraindicada
- Imipramine + Selegiline Contraindicada
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Imipramine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Imipramine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and imipramine is a tricyclic antidepressant that blocks serotonin and noradrenaline reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Imipramine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting imipramine, and at least 14 days after stopping imipramine before starting isocarboxazid.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Phenelzine, Pimozide. The full list is on the Imipramine page.
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