Interações medicamentosas
Bupropion + Rasagiline
Gravidade: Contraindicada
Bupropion and Rasagiline: contraindicated interaction.
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Resumo
Rasagiline (an irreversible MAO-B inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
O que esta interação significa em palavras simples
Bupropion and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Por que acontece
MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity
O que fazer
Do not use together. Wait at least 14 days after stopping rasagiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Bupropion
- Bupropion + Isocarboxazid Contraindicada
- Bupropion + Linezolid Contraindicada
- Bupropion + Phenelzine Contraindicada
- Bupropion + Selegiline Contraindicada
- Bupropion + Selegiline transdermal Contraindicada
- Bupropion + Thioridazine Contraindicada
Outras interações de Rasagiline
- Atomoxetine + Rasagiline Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Bupropion-naltrexone + Rasagiline Contraindicada
- Clomipramine + Rasagiline Contraindicada
- Desvenlafaxine + Rasagiline Contraindicada
- Deutetrabenazine + Rasagiline Contraindicada
Perguntas frequentes
Can I take Bupropion with Rasagiline?
MediHelp rates the interaction as contraindicated. Bupropion and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline (an irreversible MAO-B inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
How serious is the interaction between Bupropion and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping rasagiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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