Interações medicamentosas
Insulin degludec + Megestrol
Gravidade: Moderada
Insulin degludec and Megestrol: moderate interaction.
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Resumo
Megestrol, particularly at higher doses used for appetite stimulation, can raise blood glucose through glucocorticoid-like activity and reduce insulin effectiveness. Insulin requirements may rise.
O que esta interação significa em palavras simples
Insulin degludec and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Megestrol belongs to Oncology.
Por que acontece
Megestrol has glucocorticoid-like activity that promotes insulin resistance and hyperglycemia, opposing insulin action.
O que fazer
Monitor blood glucose when starting, adjusting or stopping megestrol and increase the insulin dose as needed. Reduce the insulin dose again after megestrol is discontinued.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Insulin degludec
Outras interações de Megestrol
- Dofetilide + Megestrol Contraindicada
- Insulin degludec / insulin aspart + Megestrol Moderada
- Insulin degludec-insulin aspart + Megestrol Moderada
- Insulin degludec-liraglutide + Megestrol Moderada
- Insulin inhaled + Megestrol Moderada
- Mavacamten + Megestrol Moderada
Perguntas frequentes
Can I take Insulin degludec with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol, particularly at higher doses used for appetite stimulation, can raise blood glucose through glucocorticoid-like activity and reduce insulin effectiveness. Insulin requirements may rise.
How serious is the interaction between Insulin degludec and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, adjusting or stopping megestrol and increase the insulin dose as needed. Reduce the insulin dose again after megestrol is discontinued.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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