Interações medicamentosas
Insulin degludec / insulin aspart + Megestrol
Gravidade: Moderada
Insulin degludec / insulin aspart and Megestrol: moderate interaction.
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Resumo
Megestrol has glucocorticoid-like activity and can raise blood glucose and worsen insulin resistance. Patients on insulin may therefore need higher doses to maintain glycemic control. Hyperglycemia may emerge or worsen during therapy.
O que esta interação significa em palavras simples
Insulin degludec / insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Pharmacodynamic antagonism through glucocorticoid-like effects of megestrol causing insulin resistance and reduced glucose tolerance.
O que fazer
Monitor blood glucose more frequently when megestrol is started, changed or stopped. Titrate insulin doses, and reduce them again after megestrol is withdrawn.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Megestrol
- Dofetilide + Megestrol Contraindicada
- Insulin degludec-insulin aspart + Megestrol Moderada
- Insulin degludec-liraglutide + Megestrol Moderada
- Insulin degludec + Megestrol Moderada
- Insulin inhaled + Megestrol Moderada
- Mavacamten + Megestrol Moderada
Perguntas frequentes
Can I take Insulin degludec / insulin aspart with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol has glucocorticoid-like activity and can raise blood glucose and worsen insulin resistance. Patients on insulin may therefore need higher doses to maintain glycemic control. Hyperglycemia may emerge or worsen during therapy.
How serious is the interaction between Insulin degludec / insulin aspart and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when megestrol is started, changed or stopped. Titrate insulin doses, and reduce them again after megestrol is withdrawn.
What other medicines interact with Megestrol?
MediHelp also lists interactions of Megestrol with, for example, Dofetilide, Insulin degludec-insulin aspart, Insulin degludec-liraglutide. The full list is on the Megestrol page.
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