Interações medicamentosas
Insulin degludec-insulin aspart + Megestrol
Gravidade: Moderada
Insulin degludec-insulin aspart and Megestrol: moderate interaction.
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Resumo
Megestrol has glucocorticoid-like activity and can cause hyperglycemia, worsening diabetes control and increasing insulin requirements. Effects are more evident at the higher doses used for appetite stimulation.
O que esta interação significa em palavras simples
Insulin degludec-insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Megestrol belongs to Oncology.
Por que acontece
Progestogen with glucocorticoid activity that induces insulin resistance, opposing insulin action.
O que fazer
Monitor blood glucose regularly during megestrol therapy and increase the insulin dose as needed. Reduce the insulin dose again when megestrol is stopped.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Grave
- Clozapine + Insulin degludec-insulin aspart Grave
- Diazoxide + Insulin degludec-insulin aspart Grave
- Ethanol + Insulin degludec-insulin aspart Grave
- Insulin degludec-insulin aspart + Mecasermin Grave
- Insulin degludec-insulin aspart + Pioglitazone Grave
Outras interações de Megestrol
- Dofetilide + Megestrol Contraindicada
- Insulin degludec / insulin aspart + Megestrol Moderada
- Insulin degludec-liraglutide + Megestrol Moderada
- Insulin degludec + Megestrol Moderada
- Insulin inhaled + Megestrol Moderada
- Mavacamten + Megestrol Moderada
Perguntas frequentes
Can I take Insulin degludec-insulin aspart with Megestrol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Megestrol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Megestrol has glucocorticoid-like activity and can cause hyperglycemia, worsening diabetes control and increasing insulin requirements. Effects are more evident at the higher doses used for appetite stimulation.
How serious is the interaction between Insulin degludec-insulin aspart and Megestrol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during megestrol therapy and increase the insulin dose as needed. Reduce the insulin dose again when megestrol is stopped.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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