Interações medicamentosas
Insulin degludec + Pasireotide
Gravidade: Grave
Insulin degludec and Pasireotide: major interaction.
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Resumo
Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
O que esta interação significa em palavras simples
Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Pasireotide belongs to Endocrine.
Por que acontece
Pasireotide suppresses insulin and incretin secretion (GLP-1 and GIP), producing hyperglycemia.
O que fazer
Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Insulin degludec
Outras interações de Pasireotide
- Dronedarone + Pasireotide Contraindicada
- Pasireotide + Pimozide Contraindicada
- Amiodarone + Pasireotide Grave
- Amisulpride + Pasireotide Grave
- Amitriptyline + Pasireotide Grave
- Anagrelide + Pasireotide Grave
Perguntas frequentes
Can I take Insulin degludec with Pasireotide?
MediHelp rates the interaction as major. Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
How serious is the interaction between Insulin degludec and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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