Interações medicamentosas
Isavuconazole + Phenobarbitone
Gravidade: Contraindicada
Isavuconazole and Phenobarbitone: contraindicated interaction.
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Resumo
Phenobarbitone induces hepatic CYP3A4 and can substantially reduce isavuconazole concentrations. Loss of antifungal efficacy in serious fungal infection is the main concern.
O que esta interação significa em palavras simples
Isavuconazole and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazole belongs to Anti Fungals; Phenobarbitone belongs to Central Nervous System.
Por que acontece
Phenobarbitone induces CYP3A4/5 and increases isavuconazole clearance.
O que fazer
Do not use together; select an alternative anticonvulsant or antifungal agent. If unavoidable, monitor isavuconazole levels and clinical response.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isavuconazole
- Carbamazepine + Isavuconazole Contraindicada
- Efavirenz + Isavuconazole Contraindicada
- Etravirine + Isavuconazole Contraindicada
- Isavuconazole + Ketoconazole Contraindicada
- Isavuconazole + Phenytoin Contraindicada
- Isavuconazole + Rifampicin Contraindicada
Outras interações de Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicada
- Doravirine + Phenobarbitone Contraindicada
- Darolutamide + Phenobarbitone Grave
- Finerenone + Phenobarbitone Grave
- Ivacaftor + Phenobarbitone Grave
- Letermovir + Phenobarbitone Grave
Perguntas frequentes
Can I take Isavuconazole with Phenobarbitone?
MediHelp rates the interaction as contraindicated. Isavuconazole and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenobarbitone induces hepatic CYP3A4 and can substantially reduce isavuconazole concentrations. Loss of antifungal efficacy in serious fungal infection is the main concern.
How serious is the interaction between Isavuconazole and Phenobarbitone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; select an alternative anticonvulsant or antifungal agent. If unavoidable, monitor isavuconazole levels and clinical response.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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