Drug interactions
Isavuconazole + Phenobarbitone
Severity: Contraindicated
Isavuconazole and Phenobarbitone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbitone induces hepatic CYP3A4 and can substantially reduce isavuconazole concentrations. Loss of antifungal efficacy in serious fungal infection is the main concern.
What this interaction means in plain words
Isavuconazole and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isavuconazole belongs to Anti Fungals; Phenobarbitone belongs to Central Nervous System.
Why it happens
Phenobarbitone induces CYP3A4/5 and increases isavuconazole clearance.
What to do
Do not use together; select an alternative anticonvulsant or antifungal agent. If unavoidable, monitor isavuconazole levels and clinical response.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isavuconazole
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenytoin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
- Letermovir + Phenobarbitone Major
Frequently asked questions
Can I take Isavuconazole with Phenobarbitone?
MediHelp rates the interaction as contraindicated. Isavuconazole and Phenobarbitone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenobarbitone induces hepatic CYP3A4 and can substantially reduce isavuconazole concentrations. Loss of antifungal efficacy in serious fungal infection is the main concern.
How serious is the interaction between Isavuconazole and Phenobarbitone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; select an alternative anticonvulsant or antifungal agent. If unavoidable, monitor isavuconazole levels and clinical response.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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