Interações medicamentosas
Letermovir + Phenobarbitone
Gravidade: Grave
Letermovir and Phenobarbitone: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Phenobarbitone may lower letermovir plasma concentrations, which could compromise prevention of cytomegalovirus infection in transplant recipients. Labeling advises against the combination.
O que esta interação significa em palavras simples
Letermovir and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Letermovir belongs to Anti Virals; Phenobarbitone belongs to Central Nervous System.
Por que acontece
Enzyme induction by phenobarbitone (including UGT and CYP pathways) increases letermovir clearance.
O que fazer
Avoid the combination and choose a non-inducing anticonvulsant where possible. If it cannot be avoided, monitor for CMV breakthrough.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Letermovir
- Ergotamine + Letermovir Contraindicada
- Letermovir + Pimozide Contraindicada
- Apalutamide + Letermovir Grave
- Atorvastatin + Letermovir Grave
- Carbamazepine + Letermovir Grave
- Colchicine + Letermovir Grave
Outras interações de Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicada
- Doravirine + Phenobarbitone Contraindicada
- Isavuconazole + Phenobarbitone Contraindicada
- Darolutamide + Phenobarbitone Grave
- Finerenone + Phenobarbitone Grave
- Ivacaftor + Phenobarbitone Grave
Perguntas frequentes
Can I take Letermovir with Phenobarbitone?
MediHelp rates the interaction as major. Letermovir and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenobarbitone may lower letermovir plasma concentrations, which could compromise prevention of cytomegalovirus infection in transplant recipients. Labeling advises against the combination.
How serious is the interaction between Letermovir and Phenobarbitone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing anticonvulsant where possible. If it cannot be avoided, monitor for CMV breakthrough.
What other medicines interact with Letermovir?
MediHelp also lists interactions of Letermovir with, for example, Ergotamine, Pimozide, Apalutamide. The full list is on the Letermovir page.
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