Interações medicamentosas
Isotretinoin + Palovarotene
Gravidade: Contraindicada
Isotretinoin and Palovarotene: contraindicated interaction.
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Resumo
Palovarotene is an oral retinoid, and adding isotretinoin produces additive retinoid exposure. This may cause hypervitaminosis A-type toxicity including mucocutaneous effects, hepatotoxicity, and raised intracranial pressure, along with additive teratogenicity.
O que esta interação significa em palavras simples
Isotretinoin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isotretinoin belongs to Dermatology; Palovarotene belongs to Miscellaneous.
Por que acontece
Additive pharmacodynamic retinoid receptor activity leading to hypervitaminosis A toxicity.
O que fazer
Do not combine two systemic retinoids; use only one. Select an alternative for the second indication.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isotretinoin
- Demeclocycline + Isotretinoin Contraindicada
- Isotretinoin + Minocycline Contraindicada
- Isotretinoin + Oxytetracycline Contraindicada
- Aminolevulinic acid + Isotretinoin Grave
- Doxycycline + Isotretinoin Grave
- Isotretinoin + Lomitapide Grave
Outras interações de Palovarotene
- Acitretin + Palovarotene Contraindicada
- Amiodarone + Palovarotene Grave
- Amobarbital + Palovarotene Grave
- Apalutamide + Palovarotene Grave
- Aprepitant + Palovarotene Grave
- Carbamazepine + Palovarotene Grave
Perguntas frequentes
Can I take Isotretinoin with Palovarotene?
MediHelp rates the interaction as contraindicated. Isotretinoin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Palovarotene is an oral retinoid, and adding isotretinoin produces additive retinoid exposure. This may cause hypervitaminosis A-type toxicity including mucocutaneous effects, hepatotoxicity, and raised intracranial pressure, along with additive teratogenicity.
How serious is the interaction between Isotretinoin and Palovarotene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine two systemic retinoids; use only one. Select an alternative for the second indication.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.
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