Interações medicamentosas
Demeclocycline + Isotretinoin
Gravidade: Contraindicada
Demeclocycline and Isotretinoin: contraindicated interaction.
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Resumo
Both isotretinoin and tetracyclines such as demeclocycline can independently cause raised intracranial pressure. Combined use increases the risk of pseudotumor cerebri, with headache, visual disturbance and papilledema, and potential permanent vision loss.
O que esta interação significa em palavras simples
Demeclocycline and Isotretinoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive pharmacodynamic effect on intracranial pressure; exact mechanism not established.
O que fazer
Avoid concurrent use; choose a non-tetracycline antibiotic. If headache or visual symptoms develop, stop both and obtain urgent ophthalmologic evaluation.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isotretinoin
- Isotretinoin + Minocycline Contraindicada
- Isotretinoin + Oxytetracycline Contraindicada
- Isotretinoin + Palovarotene Contraindicada
- Aminolevulinic acid + Isotretinoin Grave
- Doxycycline + Isotretinoin Grave
- Isotretinoin + Lomitapide Grave
Perguntas frequentes
Can I take Demeclocycline with Isotretinoin?
MediHelp rates the interaction as contraindicated. Demeclocycline and Isotretinoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both isotretinoin and tetracyclines such as demeclocycline can independently cause raised intracranial pressure. Combined use increases the risk of pseudotumor cerebri, with headache, visual disturbance and papilledema, and potential permanent vision loss.
How serious is the interaction between Demeclocycline and Isotretinoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a non-tetracycline antibiotic. If headache or visual symptoms develop, stop both and obtain urgent ophthalmologic evaluation.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Minocycline, Oxytetracycline, Palovarotene. The full list is on the Isotretinoin page.
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