Interações medicamentosas
Ledipasvir-sofosbuvir + Phenytoin
Gravidade: Contraindicada
Ledipasvir-sofosbuvir and Phenytoin: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.
O que esta interação significa em palavras simples
Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ledipasvir-sofosbuvir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
Por que acontece
Phenytoin induces P-glycoprotein and metabolic enzymes, reducing absorption and exposure of sofosbuvir and ledipasvir.
O que fazer
Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicada
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicada
- Ledipasvir-sofosbuvir + Rifampin Contraindicada
- Ledipasvir-sofosbuvir + Rifapentine Contraindicada
- Ledipasvir-sofosbuvir + St john's wort Contraindicada
- Ledipasvir-sofosbuvir + Tipranavir Contraindicada
Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
Perguntas frequentes
Can I take Ledipasvir-sofosbuvir with Phenytoin?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.
How serious is the interaction between Ledipasvir-sofosbuvir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Rifampin. The full list is on the Ledipasvir-sofosbuvir page.
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