Interações medicamentosas
Lomitapide + Micafungin
Gravidade: Moderada
Lomitapide and Micafungin: moderate interaction.
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Resumo
Lomitapide is highly dependent on CYP3A4 for clearance and its exposure rises markedly with inhibitors. Micafungin is only a weak inhibitor, so the effect is likely small, but increased lomitapide could worsen hepatotoxicity and gastrointestinal effects.
O que esta interação significa em palavras simples
Lomitapide and Micafungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Micafungin belongs to Anti Fungals.
Por que acontece
Possible weak inhibition of CYP3A4-mediated lomitapide metabolism by micafungin.
O que fazer
Monitor liver enzymes and tolerability; keep the lomitapide dose within labeled limits for use with weak CYP3A4 inhibitors.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Micafungin
Outras interações de Lomitapide
- Aprepitant + Lomitapide Contraindicada
- Clarithromycin + Lomitapide Contraindicada
- Crizotinib + Lomitapide Contraindicada
- Diltiazem + Lomitapide Contraindicada
- Efavirenz + Lomitapide Contraindicada
- Ensitrelvir + Lomitapide Contraindicada
Perguntas frequentes
Can I take Lomitapide with Micafungin?
MediHelp rates the interaction as moderate. Lomitapide and Micafungin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is highly dependent on CYP3A4 for clearance and its exposure rises markedly with inhibitors. Micafungin is only a weak inhibitor, so the effect is likely small, but increased lomitapide could worsen hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Lomitapide and Micafungin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability; keep the lomitapide dose within labeled limits for use with weak CYP3A4 inhibitors.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Saccharomyces boulardii, Sirolimus, Avapritinib. The full list is on the Micafungin page.
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