Interações medicamentosas
Isavuconazonium + Micafungin
Gravidade: Leve
Isavuconazonium and Micafungin: minor interaction.
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Resumo
Micafungin is a weak CYP3A4 inhibitor, and isavuconazole is a CYP3A4 substrate, so a small rise in isavuconazole exposure is theoretically possible. This is unlikely to be clinically important, and the two antifungals are sometimes used together.
O que esta interação significa em palavras simples
Isavuconazonium and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Micafungin belongs to Anti Fungals.
Por que acontece
Theoretical weak CYP3A4 inhibition by micafungin reducing isavuconazole clearance.
O que fazer
No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as liver enzyme elevation.
O que perguntar ao farmacêutico
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Outras interações de Micafungin
- Lomitapide + Micafungin Moderada
- Micafungin + Saccharomyces boulardii Moderada
- Micafungin + Sirolimus Moderada
- Avapritinib + Micafungin Leve
- Finerenone + Micafungin Leve
- Ivacaftor + Micafungin Leve
Outras interações de Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicada
- Apalutamide + Isavuconazonium Contraindicada
- Carbamazepine + Isavuconazonium Contraindicada
- Cisapride + Isavuconazonium Contraindicada
- Efavirenz + Isavuconazonium Contraindicada
- Enzalutamide + Isavuconazonium Contraindicada
Perguntas frequentes
Can I take Isavuconazonium with Micafungin?
MediHelp rates the interaction as minor. Isavuconazonium and Micafungin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Micafungin is a weak CYP3A4 inhibitor, and isavuconazole is a CYP3A4 substrate, so a small rise in isavuconazole exposure is theoretically possible. This is unlikely to be clinically important, and the two antifungals are sometimes used together.
How serious is the interaction between Isavuconazonium and Micafungin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor for isavuconazole adverse effects such as liver enzyme elevation.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
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