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Interações medicamentosas

Lomustine + Measles vaccine

Gravidade: Contraindicada

Lomustine and Measles vaccine: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Live measles vaccine can cause progressive or disseminated measles infection in patients immunosuppressed by lomustine. Vaccine response may also be inadequate.

O que esta interação significa em palavras simples

Lomustine and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: High

Por que acontece

Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.

O que fazer

Avoid during lomustine therapy and defer until immune recovery, generally at least 3 months after chemotherapy ends. Consider immunoglobulin prophylaxis if exposed to measles.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Lomustine with Measles vaccine?

MediHelp rates the interaction as contraindicated. Lomustine and Measles vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live measles vaccine can cause progressive or disseminated measles infection in patients immunosuppressed by lomustine. Vaccine response may also be inadequate.

How serious is the interaction between Lomustine and Measles vaccine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during lomustine therapy and defer until immune recovery, generally at least 3 months after chemotherapy ends. Consider immunoglobulin prophylaxis if exposed to measles.

What other medicines interact with Lomustine?

MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.

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