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Interações medicamentosas

Lomustine + Measles mumps and rubella vaccine live

Gravidade: Contraindicada

Lomustine and Measles mumps and rubella vaccine live: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

The live MMR vaccine can cause disseminated vaccine-virus infection in patients immunosuppressed by lomustine, and the antibody response may be poor.

O que esta interação significa em palavras simples

Lomustine and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: High

Por que acontece

Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.

O que fazer

Do not give during lomustine therapy; defer until immune recovery, generally at least 3 months after stopping. Check immunity serologically afterwards if needed.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Lomustine with Measles mumps and rubella vaccine live?

MediHelp rates the interaction as contraindicated. Lomustine and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live MMR vaccine can cause disseminated vaccine-virus infection in patients immunosuppressed by lomustine, and the antibody response may be poor.

How serious is the interaction between Lomustine and Measles mumps and rubella vaccine live?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give during lomustine therapy; defer until immune recovery, generally at least 3 months after stopping. Check immunity serologically afterwards if needed.

What other medicines interact with Lomustine?

MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.

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