Interações medicamentosas
Measles mumps and rubella vaccine + Tisagenlecleucel
Gravidade: Contraindicada
Measles mumps and rubella vaccine and Tisagenlecleucel: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
O que esta interação significa em palavras simples
Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Tisagenlecleucel belongs to Oncology.
Por que acontece
Pharmacodynamic: lymphodepleting chemotherapy and CAR-T mediated B-cell depletion impair control of replicating live vaccine viruses.
O que fazer
Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Measles mumps and rubella vaccine e Tisagenlecleucel, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicada
- Anakinra + Measles mumps and rubella vaccine Contraindicada
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicada
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Basiliximab + Measles mumps and rubella vaccine Contraindicada
Outras interações de Tisagenlecleucel
Perguntas frequentes
Can I take Measles mumps and rubella vaccine with Tisagenlecleucel?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
How serious is the interaction between Measles mumps and rubella vaccine and Tisagenlecleucel?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
