Interações medicamentosas
Azathioprine + Tisagenlecleucel
Gravidade: Grave
Azathioprine and Tisagenlecleucel: major interaction.
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Resumo
Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of tisagenlecleucel. Together they also add to infection risk in patients already immunocompromised.
O que esta interação significa em palavras simples
Azathioprine and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Tisagenlecleucel belongs to Oncology.
Por que acontece
Antimetabolite-driven lymphocyte suppression may blunt CAR T-cell proliferation, and the effects add to the immune deficiency caused by the therapy.
O que fazer
Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicada
- Azathioprine + Bcg vaccine live Contraindicada
- Azathioprine + Febuxostat Contraindicada
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine live Contraindicada
Outras interações de Tisagenlecleucel
Perguntas frequentes
Can I take Azathioprine with Tisagenlecleucel?
MediHelp rates the interaction as major. Azathioprine and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of tisagenlecleucel. Together they also add to infection risk in patients already immunocompromised.
How serious is the interaction between Azathioprine and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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