Interações medicamentosas
Measles mumps rubella and varicella vaccine live + Methotrexate
Gravidade: Contraindicada
Measles mumps rubella and varicella vaccine live and Methotrexate: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
This combined live vaccine contains four attenuated viruses that may replicate unchecked in patients on methotrexate, risking disseminated infection. Vaccine effectiveness may also be reduced.
O que esta interação significa em palavras simples
Measles mumps rubella and varicella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Methotrexate-induced immunosuppression impairs clearance of live attenuated viruses.
O que fazer
Do not administer during methotrexate therapy; give at least 4 weeks before starting treatment when possible, or use separate non-live alternatives where available.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Measles mumps rubella and varicella vaccine live e Methotrexate, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Methotrexate
- Acitretin + Methotrexate Contraindicada
- Adenovirus types 4 and 7 live + Methotrexate Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicada
- Ketorolac + Methotrexate Contraindicada
- Measles mumps and rubella vaccine live + Methotrexate Contraindicada
- Measles mumps and rubella vaccine + Methotrexate Contraindicada
Perguntas frequentes
Can I take Measles mumps rubella and varicella vaccine live with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This combined live vaccine contains four attenuated viruses that may replicate unchecked in patients on methotrexate, risking disseminated infection. Vaccine effectiveness may also be reduced.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during methotrexate therapy; give at least 4 weeks before starting treatment when possible, or use separate non-live alternatives where available.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
