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Interações medicamentosas

Measles mumps rubella and varicella vaccine live + Oxaliplatin

Gravidade: Contraindicada

Measles mumps rubella and varicella vaccine live and Oxaliplatin: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Combined live MMRV vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed by oxaliplatin, and immunogenicity is reduced.

O que esta interação significa em palavras simples

Measles mumps rubella and varicella vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: High

Por que acontece

Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.

O que fazer

Avoid during oxaliplatin therapy and until immune recovery, generally at least 3 months after stopping. Revaccinate once immunity has recovered.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Measles mumps rubella and varicella vaccine live with Oxaliplatin?

MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Oxaliplatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combined live MMRV vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed by oxaliplatin, and immunogenicity is reduced.

How serious is the interaction between Measles mumps rubella and varicella vaccine live and Oxaliplatin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during oxaliplatin therapy and until immune recovery, generally at least 3 months after stopping. Revaccinate once immunity has recovered.

What other medicines interact with Oxaliplatin?

MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.

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