Interações medicamentosas
Meperidine + Olanzapine / samidorphan
Gravidade: Contraindicada
Meperidine and Olanzapine / samidorphan: contraindicated interaction.
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Resumo
Samidorphan is an opioid antagonist that blocks the effect of meperidine and can precipitate acute withdrawal in opioid-dependent patients. The combination is contraindicated in patients using opioids.
O que esta interação significa em palavras simples
Meperidine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Samidorphan is a mu-opioid receptor antagonist that opposes the pharmacologic effects of opioid agonists.
O que fazer
Do not start olanzapine/samidorphan until the patient has been opioid-free for at least 7 days for short-acting opioids. Choose another antipsychotic if ongoing opioid therapy is needed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Meperidine
- Alvimopan + Meperidine Contraindicada
- Isocarboxazid + Meperidine Contraindicada
- Meperidine + Methylene blue Contraindicada
- Meperidine + Phenelzine Contraindicada
- Meperidine + Procarbazine Contraindicada
- Meperidine + Rasagiline Contraindicada
Perguntas frequentes
Can I take Meperidine with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Meperidine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks the effect of meperidine and can precipitate acute withdrawal in opioid-dependent patients. The combination is contraindicated in patients using opioids.
How serious is the interaction between Meperidine and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start olanzapine/samidorphan until the patient has been opioid-free for at least 7 days for short-acting opioids. Choose another antipsychotic if ongoing opioid therapy is needed.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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