Interações medicamentosas
Meperidine + Rasagiline
Gravidade: Contraindicada
Meperidine and Rasagiline: contraindicated interaction.
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Resumo
Rasagiline labeling warns against meperidine because of reports of serious, sometimes fatal serotonin syndrome-like reactions with MAO inhibitors. Symptoms can include agitation, hyperthermia, rigidity and autonomic instability.
O que esta interação significa em palavras simples
Meperidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meperidine belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Por que acontece
MAO inhibition combined with meperidine's serotonin reuptake inhibition increases serotonergic activity.
O que fazer
Avoid the combination and allow an adequate washout interval, generally at least 14 days after rasagiline. Use a different analgesic.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Meperidine
- Alvimopan + Meperidine Contraindicada
- Isocarboxazid + Meperidine Contraindicada
- Meperidine + Methylene blue Contraindicada
- Meperidine + Olanzapine / samidorphan Contraindicada
- Meperidine + Phenelzine Contraindicada
- Meperidine + Procarbazine Contraindicada
Outras interações de Rasagiline
- Atomoxetine + Rasagiline Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Bupropion-naltrexone + Rasagiline Contraindicada
- Bupropion + Rasagiline Contraindicada
- Clomipramine + Rasagiline Contraindicada
- Desvenlafaxine + Rasagiline Contraindicada
Perguntas frequentes
Can I take Meperidine with Rasagiline?
MediHelp rates the interaction as contraindicated. Meperidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline labeling warns against meperidine because of reports of serious, sometimes fatal serotonin syndrome-like reactions with MAO inhibitors. Symptoms can include agitation, hyperthermia, rigidity and autonomic instability.
How serious is the interaction between Meperidine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow an adequate washout interval, generally at least 14 days after rasagiline. Use a different analgesic.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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