Interações medicamentosas
Isocarboxazid + Meperidine
Gravidade: Contraindicada
Isocarboxazid and Meperidine: contraindicated interaction.
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Resumo
Meperidine blocks neuronal serotonin reuptake and, with isocarboxazid, can cause a severe reaction with agitation, hyperthermia, rigidity and sometimes coma or death. The reaction is both serotonergic and, in some cases, hypertensive.
O que esta interação significa em palavras simples
Isocarboxazid and Meperidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Por que acontece
Serotonergic toxicity (MAO inhibition plus serotonin reuptake block by meperidine)
O que fazer
Contraindicated; do not use meperidine within 14 days of an MAO inhibitor and select a non-serotonergic opioid such as morphine with caution.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Meperidine
- Alvimopan + Meperidine Contraindicada
- Meperidine + Methylene blue Contraindicada
- Meperidine + Olanzapine / samidorphan Contraindicada
- Meperidine + Phenelzine Contraindicada
- Meperidine + Procarbazine Contraindicada
- Meperidine + Rasagiline Contraindicada
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Isocarboxazid with Meperidine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Meperidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meperidine blocks neuronal serotonin reuptake and, with isocarboxazid, can cause a severe reaction with agitation, hyperthermia, rigidity and sometimes coma or death. The reaction is both serotonergic and, in some cases, hypertensive.
How serious is the interaction between Isocarboxazid and Meperidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not use meperidine within 14 days of an MAO inhibitor and select a non-serotonergic opioid such as morphine with caution.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Methylene blue, Olanzapine / samidorphan. The full list is on the Meperidine page.
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