Interações medicamentosas
Mestranol + Tranexamic acid
Gravidade: Contraindicada
Mestranol and Tranexamic acid: contraindicated interaction.
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Resumo
Oral tranexamic acid is antifibrinolytic and mestranol, a prodrug of ethinylestradiol, is prothrombotic. Together they raise the risk of venous and arterial thrombosis, and oral tranexamic acid labeling contraindicates use with combined hormonal contraceptives.
O que esta interação significa em palavras simples
Mestranol and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive prothrombotic effects of fibrinolysis inhibition and estrogen-induced increases in clotting factors.
O que fazer
Avoid the combination; use non-hormonal or progestin-only contraception while taking tranexamic acid, or choose another heavy-bleeding treatment.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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Outras interações de Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid Contraindicada
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicada
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicada
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicada
- Ethinylestradiol + Tranexamic acid Contraindicada
- Alteplase + Tranexamic acid Grave
Perguntas frequentes
Can I take Mestranol with Tranexamic acid?
MediHelp rates the interaction as contraindicated. Mestranol and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral tranexamic acid is antifibrinolytic and mestranol, a prodrug of ethinylestradiol, is prothrombotic. Together they raise the risk of venous and arterial thrombosis, and oral tranexamic acid labeling contraindicates use with combined hormonal contraceptives.
How serious is the interaction between Mestranol and Tranexamic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use non-hormonal or progestin-only contraception while taking tranexamic acid, or choose another heavy-bleeding treatment.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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