Interações medicamentosas
Methylenedioxymethamphetamine + Modafinil
Gravidade: Grave
Methylenedioxymethamphetamine and Modafinil: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
MDMA is a potent serotonergic and sympathomimetic stimulant, and combining it with modafinil may increase heart rate, blood pressure, hyperthermia and agitation. Both drugs can mask fatigue, which may lead to prolonged exertion and dehydration.
O que esta interação significa em palavras simples
Methylenedioxymethamphetamine and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS stimulant and sympathomimetic effects.
O que fazer
Advise avoiding MDMA; if exposure occurs, monitor temperature, cardiovascular parameters and hydration, with emergency care for hyperthermia or severe hypertension.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Modafinil
- Lenacapavir + Modafinil Grave
- Leniolisib + Modafinil Grave
- Lorlatinib + Modafinil Grave
- Lumateperone + Modafinil Grave
- Mavacamten + Modafinil Grave
- Modafinil + Nirogacestat Grave
Perguntas frequentes
Can I take Methylenedioxymethamphetamine with Modafinil?
MediHelp rates the interaction as major. Methylenedioxymethamphetamine and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MDMA is a potent serotonergic and sympathomimetic stimulant, and combining it with modafinil may increase heart rate, blood pressure, hyperthermia and agitation. Both drugs can mask fatigue, which may lead to prolonged exertion and dehydration.
How serious is the interaction between Methylenedioxymethamphetamine and Modafinil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding MDMA; if exposure occurs, monitor temperature, cardiovascular parameters and hydration, with emergency care for hyperthermia or severe hypertension.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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