Drug interactions
Methylenedioxymethamphetamine + Modafinil
Severity: Major
Methylenedioxymethamphetamine and Modafinil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a potent serotonergic and sympathomimetic stimulant, and combining it with modafinil may increase heart rate, blood pressure, hyperthermia and agitation. Both drugs can mask fatigue, which may lead to prolonged exertion and dehydration.
What this interaction means in plain words
Methylenedioxymethamphetamine and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS stimulant and sympathomimetic effects.
What to do
Advise avoiding MDMA; if exposure occurs, monitor temperature, cardiovascular parameters and hydration, with emergency care for hyperthermia or severe hypertension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Modafinil
- Lenacapavir + Modafinil Major
- Leniolisib + Modafinil Major
- Lorlatinib + Modafinil Major
- Lumateperone + Modafinil Major
- Mavacamten + Modafinil Major
- Modafinil + Nirogacestat Major
Frequently asked questions
Can I take Methylenedioxymethamphetamine with Modafinil?
MediHelp rates the interaction as major. Methylenedioxymethamphetamine and Modafinil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MDMA is a potent serotonergic and sympathomimetic stimulant, and combining it with modafinil may increase heart rate, blood pressure, hyperthermia and agitation. Both drugs can mask fatigue, which may lead to prolonged exertion and dehydration.
How serious is the interaction between Methylenedioxymethamphetamine and Modafinil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding MDMA; if exposure occurs, monitor temperature, cardiovascular parameters and hydration, with emergency care for hyperthermia or severe hypertension.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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