Interações medicamentosas
Mifepristone + Prednisone
Gravidade: Contraindicada
Mifepristone and Prednisone: contraindicated interaction.
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Resumo
Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.
O que esta interação significa em palavras simples
Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mifepristone belongs to Endocrine; Prednisone belongs to Endocrine.
Por que acontece
Mifepristone antagonizes glucocorticoid receptors, opposing the effect of prednisone.
O que fazer
Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Prednisone
- Bcg vaccine live + Prednisone Contraindicada
- Measles vaccine + Prednisone Contraindicada
- Prednisone + Radium-223 dichloride Contraindicada
- Prednisone + Smallpox vaccine live Contraindicada
- Adenovirus types 4 and 7 live + Prednisone Grave
- Aldesleukin + Prednisone Grave
Outras interações de Mifepristone
- Apixaban + Mifepristone Contraindicada
- Argatroban + Mifepristone Contraindicada
- Cisapride + Mifepristone Contraindicada
- Cortisone + Mifepristone Contraindicada
- Cyclosporin + Mifepristone Contraindicada
- Dabigatran etexilate + Mifepristone Contraindicada
Perguntas frequentes
Can I take Mifepristone with Prednisone?
MediHelp rates the interaction as contraindicated. Mifepristone and Prednisone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids this may precipitate adrenal insufficiency or loss of disease control, and labeling for the abortion indication lists chronic corticosteroid therapy as a contraindication.
How serious is the interaction between Mifepristone and Prednisone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. If a patient needs both, an alternative strategy should be selected by a specialist, since usual steroid doses may be ineffective.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Radium-223 dichloride. The full list is on the Prednisone page.
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