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Interações medicamentosas

Natalizumab + Vedolizumab

Gravidade: Contraindicada

Natalizumab and Vedolizumab: contraindicated interaction.

Última atualização Fontes: US FDA label

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Resumo

Both drugs block integrin-mediated lymphocyte trafficking, natalizumab broadly including the CNS and vedolizumab selectively in the gut. Combined use may raise the risk of PML and other infections.

O que esta interação significa em palavras simples

Natalizumab and Vedolizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Natalizumab belongs to Gastrointestinal Tract; Vedolizumab belongs to Gastrointestinal Tract.

Nível de evidência: Moderate

Por que acontece

Overlapping integrin antagonism causing additive impairment of lymphocyte trafficking.

O que fazer

Do not use together. If switching, stop one agent before starting the other and monitor for infection and neurological symptoms.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Referências

Perguntas frequentes

Can I take Natalizumab with Vedolizumab?

MediHelp rates the interaction as contraindicated. Natalizumab and Vedolizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs block integrin-mediated lymphocyte trafficking, natalizumab broadly including the CNS and vedolizumab selectively in the gut. Combined use may raise the risk of PML and other infections.

How serious is the interaction between Natalizumab and Vedolizumab?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If switching, stop one agent before starting the other and monitor for infection and neurological symptoms.

What other medicines interact with Natalizumab?

MediHelp also lists interactions of Natalizumab with, for example, Axicabtagene ciloleucel, Baricitinib, Belatacept. The full list is on the Natalizumab page.

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