Interações medicamentosas
Golimumab + Vedolizumab
Gravidade: Grave
Golimumab and Vedolizumab: major interaction.
Última atualização Fontes: UK SmPC
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Resumo
Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.
O que esta interação significa em palavras simples
Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Golimumab belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
Por que acontece
Additive immunosuppression via gut-selective integrin blockade and TNF-alpha inhibition.
O que fazer
Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
- GOBIVAZ 100 mg solution for injection in pre-filled pen - SmPC sections 4.3/4.5 (class statement: other biological therapeutics; "The combination of golimumab with other biological therapeutics used to treat the same conditions as golimumab, including anakinra and abatacept is not recommen") — electronic medicines compendium (UK SmPC)
Outras interações de Golimumab
- Bcg vaccine live + Golimumab Contraindicada
- Etanercept + Golimumab Contraindicada
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Golimumab + Measles mumps and rubella vaccine Contraindicada
- Golimumab + Measles mumps and rubella vaccine live Contraindicada
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicada
Outras interações de Vedolizumab
- Natalizumab + Vedolizumab Contraindicada
- Baricitinib + Vedolizumab Grave
- Certolizumab pegol + Vedolizumab Grave
- Etanercept + Vedolizumab Grave
- Smallpox vaccine live + Vedolizumab Grave
- Upadacitinib + Vedolizumab Grave
Perguntas frequentes
Can I take Golimumab with Vedolizumab?
MediHelp rates the interaction as major. Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.
How serious is the interaction between Golimumab and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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