Interações medicamentosas
Propranolol + Thioridazine
Gravidade: Contraindicada
Propranolol and Thioridazine: contraindicated interaction.
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Resumo
Thioridazine can raise propranolol concentrations, and propranolol can raise thioridazine concentrations. Because thioridazine itself prolongs the QT interval, higher levels increase the risk of torsades de pointes and sudden death.
O que esta interação significa em palavras simples
Propranolol and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Propranolol belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
Por que acontece
Mutual metabolic inhibition involving CYP2D6, with additive cardiac depressant and proarrhythmic effects.
O que fazer
Avoid concurrent use. If a beta blocker is needed with thioridazine, select one not dependent on CYP2D6 such as atenolol, though thioridazine alternatives are preferred.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Propranolol
Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Propranolol with Thioridazine?
MediHelp rates the interaction as contraindicated. Propranolol and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine can raise propranolol concentrations, and propranolol can raise thioridazine concentrations. Because thioridazine itself prolongs the QT interval, higher levels increase the risk of torsades de pointes and sudden death.
How serious is the interaction between Propranolol and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If a beta blocker is needed with thioridazine, select one not dependent on CYP2D6 such as atenolol, though thioridazine alternatives are preferred.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Propranolol page.
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