Interações medicamentosas
Rifabutin + Voriconazole
Gravidade: Contraindicada
Rifabutin and Voriconazole: contraindicated interaction.
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Resumo
Rifabutin induces voriconazole metabolism and can lower antifungal levels enough to cause treatment failure. Voriconazole also increases rifabutin exposure, raising the risk of uveitis and neutropenia.
O que esta interação significa em palavras simples
Rifabutin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rifabutin belongs to Anti Bacterial; Voriconazole belongs to Anti Fungals.
Por que acontece
Rifabutin induces CYP450 enzymes lowering voriconazole, while voriconazole inhibits CYP3A4 raising rifabutin.
O que fazer
Avoid the combination under labeling. If essential, use specialist guidance with voriconazole dose adjustment, therapeutic drug monitoring and monitoring for rifabutin toxicity.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Voriconazole
- Avanafil + Voriconazole Contraindicada
- Butabarbital + Voriconazole Contraindicada
- Carbamazepine + Voriconazole Contraindicada
- Conivaptan + Voriconazole Contraindicada
- Dihydroergotamine intranasal + Voriconazole Contraindicada
- Dihydroergotamine + Voriconazole Contraindicada
Outras interações de Rifabutin
- Cabotegravir + Rifabutin Contraindicada
- Lorlatinib + Rifabutin Contraindicada
- Apixaban + Rifabutin Grave
- Axitinib + Rifabutin Grave
- Brexpiprazole + Rifabutin Grave
- Clarithromycin + Rifabutin Grave
Perguntas frequentes
Can I take Rifabutin with Voriconazole?
MediHelp rates the interaction as contraindicated. Rifabutin and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifabutin induces voriconazole metabolism and can lower antifungal levels enough to cause treatment failure. Voriconazole also increases rifabutin exposure, raising the risk of uveitis and neutropenia.
How serious is the interaction between Rifabutin and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination under labeling. If essential, use specialist guidance with voriconazole dose adjustment, therapeutic drug monitoring and monitoring for rifabutin toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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