Interações medicamentosas
Ritonavir + Tinidazole
Gravidade: Grave
Ritonavir and Tinidazole: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Ritonavir oral solution contains ethanol, and tinidazole can provoke a disulfiram-like reaction with alcohol, causing flushing, vomiting, tachycardia and headache. The risk is tied to the alcohol-containing liquid formulation rather than ritonavir itself.
O que esta interação significa em palavras simples
Ritonavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ritonavir belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
Por que acontece
Ethanol in the ritonavir oral solution combined with tinidazole's disulfiram-like inhibition of alcohol metabolism.
O que fazer
Avoid ritonavir oral solution during tinidazole treatment and for 3 days after; use ritonavir tablets or another formulation if coadministration is needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tinidazole
- Disulfiram + Tinidazole Contraindicada
- Ethanol + Tinidazole Grave
- Fexinidazole + Tinidazole Grave
- Lopinavir + Tinidazole Grave
- Nilotinib + Tinidazole Grave
- Amiodarone + Tinidazole Moderada
Outras interações de Ritonavir
- Alfuzosin + Ritonavir Contraindicada
- Amiodarone + Ritonavir Contraindicada
- Avanafil + Ritonavir Contraindicada
- Colchicine + Ritonavir Contraindicada
- Dronedarone + Ritonavir Contraindicada
- Eletriptan + Ritonavir Contraindicada
Perguntas frequentes
Can I take Ritonavir with Tinidazole?
MediHelp rates the interaction as major. Ritonavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir oral solution contains ethanol, and tinidazole can provoke a disulfiram-like reaction with alcohol, causing flushing, vomiting, tachycardia and headache. The risk is tied to the alcohol-containing liquid formulation rather than ritonavir itself.
How serious is the interaction between Ritonavir and Tinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ritonavir oral solution during tinidazole treatment and for 3 days after; use ritonavir tablets or another formulation if coadministration is needed.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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