Interações medicamentosas
Amiodarone + Tinidazole
Gravidade: Moderada
Amiodarone and Tinidazole: moderate interaction.
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Resumo
Tinidazole is partly metabolized by CYP3A4, and amiodarone is only a weak to moderate CYP3A4 inhibitor, so a significant rise in tinidazole is unlikely. The more relevant concern is that both drugs may prolong the QT interval, with a risk of torsades de pointes.
O que esta interação significa em palavras simples
Amiodarone and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tinidazole belongs to Anti Parasitic.
Por que acontece
Additive QT prolongation, with a minor possible pharmacokinetic effect through CYP3A4 inhibition by amiodarone.
O que fazer
Obtain a baseline ECG, keep potassium and magnesium normal, and monitor QTc during co-administration. Consider an alternative antimicrobial if the QTc becomes prolonged.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Tinidazole
- Disulfiram + Tinidazole Contraindicada
- Ethanol + Tinidazole Grave
- Fexinidazole + Tinidazole Grave
- Lopinavir + Tinidazole Grave
- Nilotinib + Tinidazole Grave
- Ritonavir + Tinidazole Grave
Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Perguntas frequentes
Can I take Amiodarone with Tinidazole?
MediHelp rates the interaction as moderate. Amiodarone and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tinidazole is partly metabolized by CYP3A4, and amiodarone is only a weak to moderate CYP3A4 inhibitor, so a significant rise in tinidazole is unlikely. The more relevant concern is that both drugs may prolong the QT interval, with a risk of torsades de pointes.
How serious is the interaction between Amiodarone and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, keep potassium and magnesium normal, and monitor QTc during co-administration. Consider an alternative antimicrobial if the QTc becomes prolonged.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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