Interações medicamentosas
Safinamide + Venlafaxine
Gravidade: Contraindicada
Safinamide and Venlafaxine: contraindicated interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Safinamide, an MAO-B inhibitor, combined with venlafaxine may cause serotonin syndrome or hypertensive reactions. Safinamide labeling contraindicates use with SNRIs.
O que esta interação significa em palavras simples
Safinamide and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Safinamide belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Por que acontece
MAO-B inhibition together with serotonin-noradrenaline reuptake inhibition increases monoamine activity.
O que fazer
Do not combine. Observe at least 14 days after stopping safinamide before starting venlafaxine, and an adequate washout of venlafaxine before starting safinamide.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicada
- Methylene blue + Venlafaxine Contraindicada
- Phenelzine + Venlafaxine Contraindicada
- Procarbazine + Venlafaxine Contraindicada
- Rasagiline + Venlafaxine Contraindicada
- Selegiline transdermal + Venlafaxine Contraindicada
Outras interações de Safinamide
- Amitriptyline + Safinamide Contraindicada
- Amoxapine + Safinamide Contraindicada
- Amphetamine polistirex + Safinamide Contraindicada
- Clomipramine + Safinamide Contraindicada
- Cyclobenzaprine + Safinamide Contraindicada
- Desipramine + Safinamide Contraindicada
Perguntas frequentes
Can I take Safinamide with Venlafaxine?
MediHelp rates the interaction as contraindicated. Safinamide and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide, an MAO-B inhibitor, combined with venlafaxine may cause serotonin syndrome or hypertensive reactions. Safinamide labeling contraindicates use with SNRIs.
How serious is the interaction between Safinamide and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Observe at least 14 days after stopping safinamide before starting venlafaxine, and an adequate washout of venlafaxine before starting safinamide.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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