Interações medicamentosas
Procarbazine + Venlafaxine
Gravidade: Contraindicada
Procarbazine and Venlafaxine: contraindicated interaction.
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Resumo
Procarbazine has MAO-inhibiting properties, so combining it with venlafaxine may cause serotonin syndrome or hypertensive reactions. Evidence is mostly extrapolated from MAOI class effects.
O que esta interação significa em palavras simples
Procarbazine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Por que acontece
Weak MAO inhibition by procarbazine adds to venlafaxine's serotonin and noradrenaline reuptake inhibition.
O que fazer
Avoid the combination and allow at least 14 days after stopping procarbazine before starting venlafaxine. Use a non-serotonergic alternative if an antidepressant is needed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicada
- Methylene blue + Venlafaxine Contraindicada
- Phenelzine + Venlafaxine Contraindicada
- Rasagiline + Venlafaxine Contraindicada
- Safinamide + Venlafaxine Contraindicada
- Selegiline transdermal + Venlafaxine Contraindicada
Outras interações de Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amoxapine + Procarbazine Contraindicada
- Atomoxetine + Procarbazine Contraindicada
- Bcg vaccine live + Procarbazine Contraindicada
- Brimonidine + Procarbazine Contraindicada
Perguntas frequentes
Can I take Procarbazine with Venlafaxine?
MediHelp rates the interaction as contraindicated. Procarbazine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting properties, so combining it with venlafaxine may cause serotonin syndrome or hypertensive reactions. Evidence is mostly extrapolated from MAOI class effects.
How serious is the interaction between Procarbazine and Venlafaxine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow at least 14 days after stopping procarbazine before starting venlafaxine. Use a non-serotonergic alternative if an antidepressant is needed.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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