Interações medicamentosas
Tranexamic acid + Tretinoin
Gravidade: Grave
Tranexamic acid and Tretinoin: major interaction.
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Resumo
Tranexamic acid is antifibrinolytic and oral tretinoin used for acute promyelocytic leukaemia is associated with thrombotic events. Together they may add to the risk of thrombosis, and some labeling advises caution. The concern is chiefly with systemic tretinoin.
O que esta interação significa em palavras simples
Tranexamic acid and Tretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tranexamic acid belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Por que acontece
Additive prothrombotic effects: tranexamic acid inhibits fibrinolysis while tretinoin is associated with a procoagulant state.
O que fazer
Avoid the combination where possible, particularly in acute promyelocytic leukaemia with coagulopathy. If it is necessary, monitor for signs of venous or arterial thrombosis and coagulation parameters.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid Contraindicada
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicada
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicada
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicada
- Ethinylestradiol + Tranexamic acid Contraindicada
- Mestranol + Tranexamic acid Contraindicada
Outras interações de Tretinoin
- Doxycycline + Tretinoin Grave
- Minocycline + Tretinoin Grave
- Omadacycline + Tretinoin Grave
- Palovarotene + Tretinoin Grave
- Sarecycline + Tretinoin Grave
- Tetracycline + Tretinoin Grave
Perguntas frequentes
Can I take Tranexamic acid with Tretinoin?
MediHelp rates the interaction as major. Tranexamic acid and Tretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranexamic acid is antifibrinolytic and oral tretinoin used for acute promyelocytic leukaemia is associated with thrombotic events. Together they may add to the risk of thrombosis, and some labeling advises caution. The concern is chiefly with systemic tretinoin.
How serious is the interaction between Tranexamic acid and Tretinoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in acute promyelocytic leukaemia with coagulopathy. If it is necessary, monitor for signs of venous or arterial thrombosis and coagulation parameters.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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