藥品參考
Crizanlizumab
Crizanlizumab is a medicine in the class miscellaneous. It is used for sickle cell disease.
- 藥物類別: Miscellaneous
- 用途: sickle cell disease
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- 常見劑型
- 注射劑
- 常見規格
- 10 mg/ml
- 已知交互作用
- 1 (中度: 1)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Humanized IgG2 kappa monoclonal antibody that binds P-selectin and blocks its interactions with ligands including PSGL-1; it can also dissociate preformed P-selectin/PSGL-1 complex.
成人常用劑量（仿單摘要）
Sickle cell disease (reduce frequency of vaso-occlusive crises): 5 mg/kg by intravenous infusion over 30 minutes at Week 0, Week 2, and every 4 weeks thereafter; may be given with or without hydroxyurea
懷孕與哺乳
- 懷孕
- Unknown May cause fetal harm: in monkeys it increased fetal loss (abortions, stillbirths). Human data are insufficient. Sickle cell disease itself raises pregnancy risks. Use only if the benefit justifies the potential risk to the fetus.
- 哺乳
- Unknown No data on milk levels or infant effects. Human IgG passes into milk; effects of the small infant exposure are unknown. Weigh the benefits of breastfeeding against the mother's need for treatment.
已通報的副作用
- Headache
- Arthralgia
- Nausea
- Back pain
- Fatigue
- Abdominal pain
哪些人需要特別留意
- Infusion-related reactions (pain, nausea, vomiting, fatigue, dizziness, pruritus, diarrhea, pyrexia), some requiring hospitalization; mostly during first and second infusions. Interrupt or slow the infusion for mild/moderate reactions, discontinue for severe ones; consider premedication for later infusions.
- Infusion-related reactions can be indistinguishable from vaso-occlusive crisis events and may occur together.
- Use caution with corticosteroids in sickle cell disease unless clinically indicated; they may increase the risk of acute chest syndrome and fat embolism.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (1)
同類別的其他藥品
常見問題
What is Crizanlizumab used for?
Crizanlizumab is a medicine in the class miscellaneous. It is used for Sickle cell disease.
What side effects have been reported with Crizanlizumab?
Headache, Arthralgia, Nausea, Back pain, Fatigue, Abdominal pain.
Can Crizanlizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. May cause fetal harm: in monkeys it increased fetal loss (abortions, stillbirths). Human data are insufficient. Sickle cell disease itself raises pregnancy risks. Use only if the benefit justifies the potential risk to the fetus. Breastfeeding: Unknown. No data on milk levels or infant effects. Human IgG passes into milk; effects of the small infant exposure are unknown. Weigh the benefits of breastfeeding against the mother's need for treatment.
What does Crizanlizumab interact with?
MediHelp lists 1 known interactions for Crizanlizumab. Moderate: 1. The most serious include Exagamglogene autotemcel.
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