藥物交互作用
Crizanlizumab + Exagamglogene autotemcel
嚴重程度: 中度
Crizanlizumab and Exagamglogene autotemcel: moderate interaction.
最後更新
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摘要
Crizanlizumab given close to stem cell mobilization and myeloablative conditioning may compromise the collection of cells and the conditioning process. This could affect manufacture and engraftment of the gene-edited product.
用白話說明這項交互作用的意義
Crizanlizumab and Exagamglogene autotemcel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizanlizumab belongs to Miscellaneous; Exagamglogene autotemcel belongs to Miscellaneous.
為什麼會發生
The mechanism is not well established; crizanlizumab blocks P-selectin, which may affect stem cell mobilization and cell trafficking.
處置方式
Stop crizanlizumab at least 8 weeks before mobilization and conditioning, as stated in labeling.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Exagamglogene autotemcel 的其他交互作用
常見問題
Can I take Crizanlizumab with Exagamglogene autotemcel?
MediHelp rates the interaction as moderate. Crizanlizumab and Exagamglogene autotemcel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizanlizumab given close to stem cell mobilization and myeloablative conditioning may compromise the collection of cells and the conditioning process. This could affect manufacture and engraftment of the gene-edited product.
How serious is the interaction between Crizanlizumab and Exagamglogene autotemcel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop crizanlizumab at least 8 weeks before mobilization and conditioning, as stated in labeling.
What other medicines interact with Exagamglogene autotemcel?
MediHelp also lists interactions of Exagamglogene autotemcel with, for example, Deferasirox, Deferiprone, Deferoxamine. The full list is on the Exagamglogene autotemcel page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
