藥品參考
Linaclotide
Linaclotide is a medicine in the class gastrointestinal tract. It is used for constipation.
- 藥物類別: Gastrointestinal Tract
- 用途: constipation
最後更新 來源: US FDA label, EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Gastrointestinal Tract
- ATC 代碼
- A06AX04
- 常見劑型
- 膠囊
- 已知交互作用
- 2 (中度: 2)
- 商品名
- 3
- 國家與市場
- 2
用途
作用方式
Linaclotide and its active metabolite are guanylate cyclase-C agonists acting locally on the intestinal epithelium. Raised cGMP stimulates chloride and bicarbonate secretion via CFTR, increasing intestinal fluid and accelerating transit.
成人常用劑量（仿單摘要）
IBS-C: 290 mcg orally once daily
懷孕與哺乳
- 懷孕
- Unknown Negligibly absorbed systemically; maternal use not expected to result in fetal exposure. Available human data insufficient to inform drug-associated risk.
- 哺乳
- Safe Linaclotide and its active metabolite were not detected in milk; exposure of breastfed infants not expected. Consider benefits of breastfeeding with maternal need.
已通報的副作用
- Diarrhea
- Abdominal pain
- Flatulence
- Abdominal distension
- Viral gastroenteritis
- Headache
黑框警語
- Risk of serious dehydration in pediatric patients less than 2 years of age. Contraindicated in this age group; in neonatal mice a single clinically relevant adult oral dose caused deaths due to dehydration.
禁忌症
- Patients less than 2 years of age due to risk of serious dehydration.
- Known or suspected mechanical gastrointestinal obstruction.
哪些人需要特別留意
- Severe diarrhea may occur; post-marketing cases with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia, hyponatremia) required hospitalization or IV fluids.
- Insufficient data on GC-C intestinal expression in children under 2 years to assess risk of diarrhea and its serious consequences.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (2)
- Linaclotide + Lubiprostone Moderate
- Linaclotide + Mosapride Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Linaclotide 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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相關快速閱讀
常見問題
What is Linaclotide used for?
Linaclotide is a medicine in the class gastrointestinal tract. It is used for Constipation, Irritable bowel syndrome.
What side effects have been reported with Linaclotide?
Diarrhea, Abdominal pain, Flatulence, Abdominal distension, Viral gastroenteritis, Headache. Serious warning: Risk of serious dehydration in pediatric patients less than 2 years of age.
Can Linaclotide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Negligibly absorbed systemically; maternal use not expected to result in fetal exposure. Available human data insufficient to inform drug-associated risk. Breastfeeding: Safe. Linaclotide and its active metabolite were not detected in milk; exposure of breastfed infants not expected. Consider benefits of breastfeeding with maternal need.
What does Linaclotide interact with?
MediHelp lists 2 known interactions for Linaclotide. Moderate: 2. The most serious include Lubiprostone, Mosapride.
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