藥物交互作用
Linaclotide + Mosapride
嚴重程度: 中度
Linaclotide and Mosapride: moderate interaction.
最後更新 來源: US FDA label
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摘要
Mosapride is a prokinetic and linaclotide a secretagogue, and together they may increase the risk of diarrhea, cramping and dehydration. No formal interaction studies are known, so the concern is predicted from pharmacology. Diarrhea is already the most common adverse effect of linaclotide.
用白話說明這項交互作用的意義
Linaclotide and Mosapride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linaclotide belongs to Gastrointestinal Tract; Mosapride belongs to Gastrointestinal Tract.
為什麼會發生
Pharmacodynamic: mosapride is a 5-HT4 agonist that increases gut motility, while linaclotide activates guanylate cyclase-C and increases intestinal fluid secretion and transit.
處置方式
Avoid routine combination. If used together, start at low doses and counsel patients about hydration.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
Mosapride 的其他交互作用
Linaclotide 的其他交互作用
常見問題
Can I take Linaclotide with Mosapride?
MediHelp rates the interaction as moderate. Linaclotide and Mosapride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mosapride is a prokinetic and linaclotide a secretagogue, and together they may increase the risk of diarrhea, cramping and dehydration. No formal interaction studies are known, so the concern is predicted from pharmacology. Diarrhea is already the most common adverse effect of linaclotide.
How serious is the interaction between Linaclotide and Mosapride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination. If used together, start at low doses and counsel patients about hydration.
What other medicines interact with Mosapride?
MediHelp also lists interactions of Mosapride with, for example, Lubiprostone, Prucalopride. The full list is on the Mosapride page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
