藥品參考
Linzagolix
Linzagolix is a medicine in the class endocrine. It is used for endometriosis.
- 藥物類別: Endocrine
- 用途: endometriosis
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Endocrine
- ATC 代碼
- H01CC04
- 已知交互作用
- 3 (嚴重: 3)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Selective, non-peptide GnRH receptor antagonist that competitively binds pituitary GnRH receptors, inhibiting endogenous GnRH signalling and modulating the hypothalamic-pituitary-gonadal axis.
成人常用劑量（仿單摘要）
Uterine fibroids: 100 mg or, if needed, 200 mg orally once daily with concomitant add-back therapy (estradiol 1 mg and norethisterone acetate 0.5 mg tablet once daily)
懷孕與哺乳
- 懷孕
- Unsafe Contraindicated in pregnancy; animal studies show possible increased early pregnancy loss; discontinue if pregnancy confirmed.
- 哺乳
- Unsafe Contraindicated during breast-feeding; excreted in animal milk, human excretion unknown.
已通報的副作用
- Hot flush
- Headache
- Mood disorders
- Elevated liver enzymes
- Decreased bone mineral density
- Nausea/vomiting
禁忌症
- Hypersensitivity to the active substance or excipients
- Pregnancy or breast-feeding
- Known osteoporosis
哪些人需要特別留意
- Bone mineral density loss (> 3-8% in some women); consider risk factors, DXA before treatment in at-risk patients and after 1 year; discontinue if risks outweigh benefit
- Effective non-hormonal contraception required; not shown to provide contraception; amenorrhoea may mask pregnancy
- Liver enzyme elevations; discontinue if jaundice develops; monitor in women with abnormal hepatic history
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (3)
- Linzagolix + Paclitaxel Major
- Linzagolix + Repaglinide Major
- Linzagolix + Sorafenib Major
常見問題
What is Linzagolix used for?
Linzagolix is a medicine in the class endocrine. It is used for Endometriosis, Uterine fibroids.
What side effects have been reported with Linzagolix?
Hot flush, Headache, Mood disorders, Elevated liver enzymes, Decreased bone mineral density, Nausea/vomiting.
Can Linzagolix be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; animal studies show possible increased early pregnancy loss; discontinue if pregnancy confirmed. Breastfeeding: Unsafe. Contraindicated during breast-feeding; excreted in animal milk, human excretion unknown.
What does Linzagolix interact with?
MediHelp lists 3 known interactions for Linzagolix. Major: 3. The most serious include Paclitaxel, Repaglinide, Sorafenib.
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