藥物交互作用
Linzagolix + Sorafenib
嚴重程度: 嚴重
Linzagolix and Sorafenib: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Linzagolix may increase sorafenib concentrations through CYP2C8 inhibition, raising the risk of dose-related toxicity such as hand-foot reactions and hypertension.
用白話說明這項交互作用的意義
Linzagolix and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linzagolix belongs to Endocrine; Sorafenib belongs to Oncology.
為什麼會發生
Inhibition of CYP2C8 by linzagolix reduces sorafenib clearance.
處置方式
Avoid combination where possible; otherwise monitor for sorafenib adverse effects and reduce dose as needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Linzagolix 的其他交互作用
Sorafenib 的其他交互作用
常見問題
Can I take Linzagolix with Sorafenib?
MediHelp rates the interaction as major. Linzagolix and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linzagolix may increase sorafenib concentrations through CYP2C8 inhibition, raising the risk of dose-related toxicity such as hand-foot reactions and hypertension.
How serious is the interaction between Linzagolix and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible; otherwise monitor for sorafenib adverse effects and reduce dose as needed.
What other medicines interact with Linzagolix?
MediHelp also lists interactions of Linzagolix with, for example, Paclitaxel, Repaglinide. The full list is on the Linzagolix page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
