藥品參考
Lubiprostone
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for constipation.
- 藥物類別: Gastrointestinal Tract
- 用途: constipation
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Gastrointestinal Tract
- 常見劑型
- 膠囊
- 常見規格
- 24 mcg, 8 mcg
- 已知交互作用
- 3 (中度: 2 · 輕微: 1)
- 商品名
- 12
- 國家與市場
- 2
用途
作用方式
Locally acting chloride channel activator; increases intestinal fluid secretion and intestinal motility; acts locally at apical portion of intestine.
成人常用劑量（仿單摘要）
Irritable Bowel Syndrome With Constipation: 8 mcg PO BID
懷孕與哺乳
- 懷孕
- Unknown Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices.
- 哺乳
- Safe No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
已通報的副作用
- Headache
- Diarrhea
- Nausea
禁忌症
- Hypersensitivity
- Mechanical GI obstruction
哪些人需要特別留意
- Syncope and hypotension reported, some of which required hospitalization; most cases occurred in patients taking 24 mcg twice daily and some occurred within hours.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (3)
- Linaclotide + Lubiprostone Moderate
- Lubiprostone + Mosapride Moderate
- Deflazacort + Lubiprostone Minor
常見問題
What is Lubiprostone used for?
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for Constipation, Irritable bowel syndrome.
What side effects have been reported with Lubiprostone?
Headache, Diarrhea, Nausea.
Can Lubiprostone be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices. Breastfeeding: Safe. No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
What does Lubiprostone interact with?
MediHelp lists 3 known interactions for Lubiprostone. Moderate: 2 · Minor: 1. The most serious include Linaclotide, Mosapride, Deflazacort.
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