藥品參考
Pegfilgrastim
Pegfilgrastim is a medicine in the class miscellaneous. It is used for neutropenia.
- 藥物類別: Miscellaneous
- 用途: neutropenia
最後更新
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重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- L03AA13
- 常見劑型
- 注射劑
- 常見規格
- 6 mg/.6 ml, 6 mg, 6 mg/0.6 ml
- 已知交互作用
- 1 (中度: 1)
- 商品名
- 25
- 國家與市場
- 3
用途
作用方式
Recombinant PEG-conjugated human G-CSF; acts on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end-cell functional activation
成人常用劑量（仿單摘要）
Prevention of Chemotherapy-induced Neutropenia: 6 mg SC once per chemotherapy cycle
懷孕與哺乳
- 懷孕
- Unknown Limited pegfilgrastim data; filgrastim studies show no link to birth defects or miscarriage. No harm in rats at 10 times the dose; rabbit fetal loss only with maternal toxicity. EU label: not recommended in pregnancy or without contraception. Filgrastim has more data; use only if clearly needed.
- 哺乳
- Safe No milk data for pegfilgrastim. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. LactMed (filgrastim record, covers pegfilgrastim): G-CSFs pass poorly into milk and are not absorbed by the infant's gut, so harm is unlikely; some advise pausing feeds for 3 days.
已通報的副作用
- Bone pain
- Pain in extremity
- Leukocytosis
- Sickle cell crisis
哪些人需要特別留意
- Severe and sometimes fatal sickle cell crises can occur in patients with sickle cell disorders; discontinue therapy if sickle cell crisis occurs
- ARDS reported; evaluate symptoms, including fever, pulmonary infiltrates, or respiratory distress; discontinue if ARDS occurs
- Rare cases of splenic rupture may occur; evaluate if patient experiences left upper abdominal and/or shoulder tip pain
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (1)
- Ifosfamide + Pegfilgrastim Moderate
常見問題
What is Pegfilgrastim used for?
Pegfilgrastim is a medicine in the class miscellaneous. It is used for Neutropenia, Radiation syndrome.
What side effects have been reported with Pegfilgrastim?
Bone pain, Pain in extremity, Leukocytosis, Sickle cell crisis.
Can Pegfilgrastim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited pegfilgrastim data; filgrastim studies show no link to birth defects or miscarriage. No harm in rats at 10 times the dose; rabbit fetal loss only with maternal toxicity. EU label: not recommended in pregnancy or without contraception. Filgrastim has more data; use only if clearly needed. Breastfeeding: Safe. No milk data for pegfilgrastim. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. LactMed (filgrastim record, covers pegfilgrastim): G-CSFs pass poorly into milk and are not absorbed by the infant's gut, so harm is unlikely; some advise pausing feeds for 3 days.
What does Pegfilgrastim interact with?
MediHelp lists 1 known interactions for Pegfilgrastim. Moderate: 1. The most serious include Ifosfamide.
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