藥物交互作用
Ifosfamide + Pegfilgrastim
嚴重程度: 中度
Ifosfamide and Pegfilgrastim: moderate interaction.
最後更新
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摘要
Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
用白話說明這項交互作用的意義
Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Pegfilgrastim belongs to Miscellaneous.
為什麼會發生
Growth factor-induced proliferation of myeloid progenitors increases their susceptibility to cytotoxic chemotherapy.
處置方式
Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ifosfamide 的其他交互作用
常見問題
Can I take Ifosfamide with Pegfilgrastim?
MediHelp rates the interaction as moderate. Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
How serious is the interaction between Ifosfamide and Pegfilgrastim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
