藥物交互作用
Abobotulinumtoxina + Dicyclomine
嚴重程度: 中度
Abobotulinumtoxina and Dicyclomine: moderate interaction.
最後更新
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摘要
Botulinum toxin blocks acetylcholine release at the neuromuscular junction and autonomic synapses. Anticholinergics such as dicyclomine can add to these effects, increasing generalized weakness or systemic anticholinergic effects such as dry mouth, urinary retention and constipation.
用白話說明這項交互作用的意義
Abobotulinumtoxina and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive anticholinergic and cholinergic transmission blockade at neuromuscular and autonomic synapses.
處置方式
Monitor for excessive weakness, swallowing or breathing difficulty and anticholinergic symptoms after injection. Reduce or stop dicyclomine if these occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dicyclomine 的其他交互作用
常見問題
Can I take Abobotulinumtoxina with Dicyclomine?
MediHelp rates the interaction as moderate. Abobotulinumtoxina and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Botulinum toxin blocks acetylcholine release at the neuromuscular junction and autonomic synapses. Anticholinergics such as dicyclomine can add to these effects, increasing generalized weakness or systemic anticholinergic effects such as dry mouth, urinary retention and constipation.
How serious is the interaction between Abobotulinumtoxina and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive weakness, swallowing or breathing difficulty and anticholinergic symptoms after injection. Reduce or stop dicyclomine if these occur.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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