藥物交互作用
Abobotulinumtoxina + Streptomycin
嚴重程度: 嚴重
Abobotulinumtoxina and Streptomycin: major interaction.
最後更新
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摘要
Aminoglycosides impair neuromuscular transmission and can amplify the effect of botulinum toxin. This may produce excessive or widespread muscle weakness, including swallowing and breathing difficulty.
用白話說明這項交互作用的意義
Abobotulinumtoxina and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive neuromuscular blockade, with aminoglycosides reducing presynaptic acetylcholine release.
處置方式
Avoid the combination where possible, or monitor closely for generalized weakness, dysphagia and respiratory compromise. Consider a lower toxin dose and delay streptomycin if feasible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Streptomycin 的其他交互作用
常見問題
Can I take Abobotulinumtoxina with Streptomycin?
MediHelp rates the interaction as major. Abobotulinumtoxina and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides impair neuromuscular transmission and can amplify the effect of botulinum toxin. This may produce excessive or widespread muscle weakness, including swallowing and breathing difficulty.
How serious is the interaction between Abobotulinumtoxina and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor closely for generalized weakness, dysphagia and respiratory compromise. Consider a lower toxin dose and delay streptomycin if feasible.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Adefovir, Amikacin, Amphotericin b deoxycholate. The full list is on the Streptomycin page.
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