藥物交互作用
Amphotericin b deoxycholate + Streptomycin
嚴重程度: 嚴重
Amphotericin b deoxycholate and Streptomycin: major interaction.
最後更新
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摘要
Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
用白話說明這項交互作用的意義
Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive nephrotoxicity, with impaired renal function increasing aminoglycoside accumulation and ototoxicity.
處置方式
Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Streptomycin 的其他交互作用
常見問題
Can I take Amphotericin b deoxycholate with Streptomycin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
How serious is the interaction between Amphotericin b deoxycholate and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
