藥物交互作用
Adefovir + Cisplatin
嚴重程度: 嚴重
Adefovir and Cisplatin: major interaction.
最後更新
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摘要
Both drugs can damage the renal tubules. Their combination may produce additive kidney injury and raise adefovir exposure, which can worsen nephrotoxicity.
用白話說明這項交互作用的意義
Adefovir and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Adefovir belongs to Anti Virals; Cisplatin belongs to Oncology.
為什麼會發生
Additive tubular nephrotoxicity, with reduced renal elimination of adefovir.
處置方式
Avoid the combination if possible. Otherwise monitor creatinine, phosphate and electrolytes frequently and adjust adefovir to renal function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Adefovir 的其他交互作用
Cisplatin 的其他交互作用
常見問題
Can I take Adefovir with Cisplatin?
MediHelp rates the interaction as major. Adefovir and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can damage the renal tubules. Their combination may produce additive kidney injury and raise adefovir exposure, which can worsen nephrotoxicity.
How serious is the interaction between Adefovir and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. Otherwise monitor creatinine, phosphate and electrolytes frequently and adjust adefovir to renal function.
What other medicines interact with Adefovir?
MediHelp also lists interactions of Adefovir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Amikacin, Amphotericin b. The full list is on the Adefovir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
