藥物交互作用
Adefovir + Pentamidine
嚴重程度: 嚴重
Adefovir and Pentamidine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Systemic pentamidine is nephrotoxic and can cause electrolyte disturbance, and adefovir also injures the proximal tubule. Combined use raises the risk of renal impairment.
用白話說明這項交互作用的意義
Adefovir and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Adefovir belongs to Anti Virals; Pentamidine belongs to Anti Parasitic.
為什麼會發生
Additive nephrotoxicity affecting renal tubular function.
處置方式
Avoid concurrent use when alternatives exist; otherwise monitor creatinine, electrolytes and phosphate frequently and adjust adefovir dosing to renal function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Adefovir 的其他交互作用
Pentamidine 的其他交互作用
常見問題
Can I take Adefovir with Pentamidine?
MediHelp rates the interaction as major. Adefovir and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine is nephrotoxic and can cause electrolyte disturbance, and adefovir also injures the proximal tubule. Combined use raises the risk of renal impairment.
How serious is the interaction between Adefovir and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when alternatives exist; otherwise monitor creatinine, electrolytes and phosphate frequently and adjust adefovir dosing to renal function.
What other medicines interact with Adefovir?
MediHelp also lists interactions of Adefovir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Amikacin, Amphotericin b. The full list is on the Adefovir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
